Lausecker F1, Tian X2, Inoue K2, Wang Z2, Pedigo CE2, Hassan H2, Liu C2, Zimmer M2, Jinno S2, Huckle. AL1, Hamidi H1, Ross RS3, Zent R4, Ballestrem C5, Lennon R6, Ishibe S.

Vinculin is required to maintain glomerular barrier integrity.

Kidney Int. 2017 Dec 11. pii: S0085-2538(17)30771-8.

Pubmed

Paul Atherton, Franziska Lausecker, Andrew Harrison, Christoph Ballestrem.

Low-intensity pulsed ultrasound promotes cell motility through vinculin-controlled Rac1 GTPase activity.

J Cell Sci 2017 130: 2277-2291; 

Pubmed

Paul Atherton and Christoph Ballestrem.

Talin gets SHANKed in the fight for integrin activation.

Nat Cell Biol. 2017 Mar 31;19(4):265-267.

Pubmed

Stutchbury B, Atherton P, Tsang R, Wang DY, Ballestrem C.

Distinct focal adhesion protein modules control different aspects of mechanotransduction.

J Cell Sci. 2017 May 1;130(9):1612-1624.

Pubmed

K.A.Jansen, P. Atherton, C. Ballestrem.

Mechanotransduction at the cell-matrix interface.

Semin Cell Dev Biol. 2017 Nov;71:75-83.

Pubmed

Zacharchenko T, Qian X, Goult BT, Jethwa D, Almeida TB, Ballestrem C, Critchley DR, Lowry DR, Barsukov I

Recognition by Talin: Structure of the Talin-DLC1 Complex.

Structure 2016 Jul 6. 24(7):1130-41

Pubmed

Horton ER, Humphries JD, Stutchbury B, Jacquemet G, Ballestrem C, Barry ST, Humphries MJ.

Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition. 

J Cell Biol. 2016 Feb 1. 212(3):349-364

Pubmed

Atherton P, Stutchbury B, Jethwa D, Ballestrem C.

Mechanosensitive components of integrin adhesions: Role of vinculin.

Exp Cell Res. 2015 Nov 24. pii: S0014-4827(15)30160-9.

Pubmed

Atherton P, Stutchbury B, Wang DY, Jethwa D, Tsang R, Meiler-Rodriguez E, Wang P, Bate N, Zent R, Barsukov IL, Goult BT, Critchley DR, Ballestrem C.
Vinculin controls talin engagement with the actomyosin machinery

Nat. Com. 2015 Dec 4;6:10038

Pubmed

Nijenhuis N, Zhao X, Carisey A, Ballestrem C, Derby B. (2014)
Combining AFM and acoustic probes to reveal changes in the elastic stiffness tensor of living cells. 
Biophys J. 107, 1502-12.

Pubmed

Stroud MJ, Nazgiewicz A, McKenzie EA, Wang Y, Kammerer RA, Ballestrem C. (2014)
GAS2-like proteins mediate communication between microtubules and actin through interactions with end-binding proteins. 
J Cell Science. 127, 2672-82.

Pubmed

Goult BT, Zacharchenko T, Bate N, Tsang R, Hey F, Gingras AR, Elliott PR, Roberts GC, Ballestrem C, Critchley DR, Barsukov IL. (2013) 
RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover. 
J Biol Chem. 288, 8238-49. 

Pubmed

Morgan MR, Hamidi H, Bass MD, Warwood S, Ballestrem C, Humphries MJ. (2013). 
Syndecan-4 phosphorylation is a control point for integrin recycling. 
Dev Cell. 24, 472-85. 

Pubmed

Carisey A, Tsang R, Greiner AM, Nijenhuis N, Heath N, Nazgiewicz A, Kemkemer R, Derby B, Spatz J, Ballestrem C. (2013). 
Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent manner. 
Curr Biol. 23, 271-81. 

Pubmed

Alves-Silva, J., Sánchez-Soriano, N., Beaven, R., Klein, M., Parkin, J., Millard, T.H., Bellen, H.J., Venken, K.J., Ballestrem, C., Kammerer, R.A. and Prokop, A. (2012).
Spectraplakins promote microtubule-mediated axonal growth by functioning as structural microtubule-associated proteins and EB1-dependent +TIPs (tip interacting proteins). 
J Neurosci. 32, 9143-58.

Pubmed

Deakin, N.O., Ballestrem, C. and Turner, C.E. (2012). 
Paxillin and Hic-5 interaction with vinculin is differentially regulated by Rac1 and RhoA. 
PLoS One. 7, e37990. 

Pubmed

Mathew, S., Lu, Z., Palamuttam, R.J., Mernaugh, G., Hadziselimovic, A., Chen, J., Bulus, N., Gewin, L.S., Voehler, M., Meves, A., Ballestrem, C., Fässler, R., Pozzi, A., Sanders, C.R. and Zent, R. (2012). 
β1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins. 
Mol Cell Biol. 32, 4080-91. 

Pubmed

Zhao, X., Akhtar, R., Nijenhuis, N., Wilkinson, S.J., Murphy, L., Ballestrem, C., Sherratt, M.J., Watson, R.E. and Derby, B. (2012). 
Multi-layer phase analysis: quantifying the elastic properties of soft tissues and live cells with ultra-high-frequency scanning acoustic microscopy. 
IEEE Trans Ultrason Ferroelectr Freq Control. 59, 610-20. 

Pubmed

Carisey, A., Stroud, M., Tsang, R. and Ballestrem, C. (2011). 
Fluorescence recovery after photobleaching. 
Methods Mol Biol. 769, 387-402. 

Pubmed

Stroud, M. J., Kammerer, R. A. and Ballestrem, C. (2011). 
Characterisation of GAS2-like 3, a new microtubule and actin-binding protein related to spectraplakins. 
J Biol Chem. 286, 24987-95. 

Pubmed

Wang, P., Ballestrem, C. and Streuli, C.H. (2011). 
The C’-terminus of talin links integrins to cell cycle progression. 
J Cell Biol. 195, 499-513. 

Pubmed

Rooney, C., White, G., Nazgiewicz, A., Woodcock, S. A., Anderson, K. I., Ballestrem, C., and Malliri, A. (2010) 
The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassembly. 
EMBO Rep. 11, 292-8. 

Pubmed

Goldyn, A. M., Kaiser, P., Spatz, J. P., Ballestrem, C., and Kemkemer, R. (2010) 
The kinetics of force-induced cell reorganization depend on microtubules and actin, Cytoskeleton.
Cytokeleton. 67, 241-50. 

Pubmed

Carisey, A., and Ballestrem, C. (2010) 
Vinculin, an adapter protein in control of cell adhesion signalling. 
Eur J Cell Biol. 90, 157-63. 

Pubmed

Askari, J. A., Tynan, C. J., Webb, S. E., Martin-Fernandez, M. L., Ballestrem, C., and Humphries, M. J. (2010) 
Focal adhesions are sites of integrin extension. 
J Cell Biol. 188, 891-903. 

Pubmed

Zilberman, Y., Ballestrem, C., Carramusa, L., Mazitschek, R., Khochbin, S., and Bershadsky, A. (2009) 
Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6. 
J Cell Sci. 122, 3531-41. 

Pubmed

Sanchez-Soriano, N., Goncalves-Pimentel, C., Beaven, R., Haessler, U., Ofner-Ziegenfuss, L., Ballestrem, C., and Prokop, A. (2009) 
Drosophila growth cones: A genetically tractable platform for the analysis of axonal growth dynamics. 
Dev Neurobiol. 70, 58-71. 

Pubmed

Goldyn, A. M., Rioja, B. A., Spatz, J. P., Ballestrem, C., and Kemkemer, R. (2009) 
Force-induced cell polarisation is linked to RhoA-driven microtubule-independent focal-adhesion sliding. 
J Cell Sci. 122, 3644-51. 

Pubmed

Deakin, N. O., Bass, M. D., Warwood, S., Schoelermann, J., Mostafavi-Pour, Z., Knight, D., Ballestrem, C., and Humphries, M. J. (2009) 
An integrin-α4-14-3-3ζ-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration. 
J Cell Sci. 122, 1654-64. 

Pubmed

Humphries, J. D., Wang, P., Streuli, C., Geiger, B., Humphries, M. J., and Ballestrem, C. (2007) 
Vinculin controls focal adhesion formation by direct interactions with talin and actin. 
J Cell Biol. 179, 1043-57. 

Pubmed

Carramusa, L., Ballestrem, C., Zilberman, Y., and Bershadsky, A. D. (2007) 
Mammalian diaphanous-related formin Dia1 controls the organization of E-cadherin-mediated cell-cell junctions. 
J Cell Sci. 120, 3870-82. 

Pubmed

Bass, M. D., Roach, K. A., Morgan, M. R., Mostafavi-Pour, Z., Schoen, T., Muramatsu, T., Mayer, U., Ballestrem, C., Spatz, J. P., and Humphries, M. J. (2007)

Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix. J Cell Biol. 177, 527-38.

Pubmed

Bershadsky, A. D., Ballestrem, C., Carramusa, L., Zilberman, Y., Gilquin, B., Khochbin, S., Alexandrova, A. Y., Verkhovsky, A. B., Shemesh, T., and Kozlov, M. M. (2006) 
Assembly and mechanosensory function of focal adhesions: experiments and models. 
Eur J Cell Biol. 85, 165-73. 

Pubmed

Ballestrem, C., Erez, N., Kirchner, J., Kam, Z., Bershadsky, A., and Geiger, B. (2006) 
Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer. 
J Cell Sci. 119, 866-75. 

Pubmed

Iyer, V. V., Ballestrem, C., Kirchner, J., Geiger, B., and Schaller, M. D. (2005) 
Measurement of protein tyrosine phosphorylation in cell adhesion. 
Methods Mol Biol. 294, 289-302.

Pubmed 

Ballestrem, C., and Geiger, B. (2005) 
Application of microscope-based FRET to study molecular interactions in focal adhesions of live cells. 
Methods Mol Biol. 294, 321-34.

Pubmed 

Lehnert, D., Wehrle-Haller, B., David, C., Weiland, U., Ballestrem, C., Imhof, B. A., and Bastmeyer, M. (2004) 
Cell behaviour on micropatterned substrata: limits of extracellular matrix geometry for spreading and adhesion. 
J Cell Sci. 117, 41-52. 

Pubmed

Zaidel-Bar, R., Ballestrem, C., Kam, Z., and Geiger, B. (2003) 
Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells. 
J Cell Sci.116, 4605-13. 

Pubmed

Hinz, B., Dugina, V., Ballestrem, C., Wehrle-Haller, B., and Chaponnier, C. (2003) 
Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts. 
Mol Biol Cell. 14, 2508-19. 
PubMed

Ballestrem, C., Hinz, B., Imhof, B. A., and Wehrle-Haller, B. (2001) 
Marching at the front and dragging behind: differential alphaVbeta3-integrin turnover regulates focal adhesion behavior. 
J Cell Biol. 155, 1319-32.

Pubmed

Aurrand-Lions, M., Duncan, L., Ballestrem, C., and Imhof, B. A. (2001) 
JAM-2, a novel immunoglobulin superfamily molecule, expressed by endothelial and lymphatic cells. 
J Biol Chem. 276, 2733-41. 

Pubmed

Wong, C. W., Wiedle, G., Ballestrem, C., Wehrle-Haller, B., Etteldorf, S., Bruckner, M., Engelhardt, B., Gisler, R. H., and Imhof, B. A. (2000) 
PECAM-1/CD31 trans-homophilic binding at the intercellular junctions is independent of its cytoplasmic domain; evidence for heterophilic interaction with integrin alphavbeta3 in Cis. 
Mol Biol Cell. 11, 3109-21. 

Pubmed

Ballestrem, C., Wehrle-Haller, B., Hinz, B., and Imhof, B. A. (2000) 
Actin-dependent lamellipodia formation and microtubule-dependent tail retraction control-directed cell migration. 
Mol Biol Cell. 11, 2999-3012. 

Pubmed

Horton, M. , Charras, G., Ballestrem, C., Lehenkari, P. (2000)

Integration of Atomic Force and Confocal Microscopy

Single Mol. 1, 135-37

Scopus

Merrifield, C. J., Moss, S. E., Ballestrem, C., Imhof, B. A., Giese, G., Wunderlich, I., and Almers, W. (1999) 
Endocytic vesicles move at the tips of actin tails in cultured mast cells. 
Nat Cell Biol 1, 72-4. 

Pubmed

Ballestrem, C., Wehrle-Haller, B., and Imhof, B. A. (1998) 
Actin dynamics in living mammalian cells. 
J Cell Sci. 111,1649-58. 

Pubmed

Hangan D, Morris VL, Boeters L, von Ballestrem C, Uniyal S, Chan BM. (1997)
An epitope on VLA-6 (alpha6beta1) integrin involved in migration but not adhesion is required for extravasation of murine melanoma B16F1 cells in liver.
Cancer Res. 57,3812-7.

Pubmed

Fehlner-Gardiner C, Uniyal S, von Ballestrem C, Dougherty GJ, Chan BM.
Integrin VLA-6 (alpha 6 beta 1) mediates adhesion of mouse bone marrow-derived mast cells to laminin.
Allergy. 51,650-6.

Pubmed

Fehlner-Gardiner CC, Uniyal S, von Ballestrem CG, Chan BM.
Differential utilization of VLA-4 (alpha 4 beta 1) and -5 (alpha 5 beta 1) integrins during the development of mouse bone marrow-derived mast cells.
Differentiation. 60,317-25.

Pubmed

Hangan D, Uniyal S, Morris VL, MacDonald IC, von Ballestrem C, Chau T, Schmidt EE, Chambers AF, Groom AC, Chan BM.
Integrin VLA-2 (alpha2beta1) function in postextravasation movement of human rhabdomyosarcoma RD cells in the liver.
Cancer Res. 1996 56,3142-9.

Pubmed

Von Ballestrem CG, Uniyal S, McCormick JI, Chau T, Singh B, Chan BM.
VLA-beta 1 integrin subunit-specific monoclonal antibodies MB1.1 and MB1.2: binding to epitopes not dependent on thymocyte development or regulated by phorbol ester and divalent cations.
Hybridoma. 15,125-32.

Pubmed

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Contact us

+44 (0) 161 275 1708

Christoph.Ballestrem [a] manchester.ac.uk

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